![]() In the seminal publication, Nasreddine and colleagues (2005) reported a sensitivity level for MCI and mild Alzheimer's disease (AD) of 90% and 100%, respectively. The Montreal Cognitive Assessment (MoCA) was introduced in 2005 as a brief (10 min) screening instrument to assist physicians with the detection of mild cognitive impairment (MCI Nasreddine et al., 2005). Mild cognitive impairment, Neuroimaging (structural) Introduction These results suggest that additional studies are needed to define the significance of MoCA scores relative to brain integrity among an older population. In contrast, total brain volume correlated significantly with total score on the RBANS. ![]() Modest correlations between individual subscales of the MoCA and neuroimaging variables were evident, but no patterns of shared variance emerged between the MoCA total score and neuroimaging indices. The results revealed significant correlations between the total score on the MoCA and total score on the RBANS and MMSE, though the strength of the correlations was more robust between the MoCA and the RBANS. A subset of participants ( N = 69) underwent structural 3 T magnetic resonance imaging (MRI) to define the volumes of total frontal gray matter, total hippocampus, T2-weighted subcortical hyperintensities (SH), and total brain volume. Participants were administered the MoCA, Mini-Mental State Exam (MMSE), and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The present study examined performances on the MoCA among 111 non-clinical older adults (ages 51–85) enrolled in a prospective study of cognitive aging. To date, limited information is available regarding the neuroimaging signatures associated with performance on the scale, or the relationship between the MoCA and more comprehensive cognitive screening measures. The Montreal Cognitive Assessment (MoCA) screen was developed as a brief instrument to identify mild cognitive impairment and dementia among older individuals.
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